Examining the Underlying Mechanisms of Postoperative Cognitive Dysfunction in Female Rats
Bryan first obtained his associate’s degree at community college before earning a B.A. in Biological Psychology from California State University. During his undergraduate training, he investigated how serotonergic signaling mediates cognitive rigidity in a mouse model of autism spectrum disorder. In 2022, Bryan joined NGP, where he trained in the laboratory of Dr. Ruth Barrientos. His research examines how modifiable risk factors contribute to the transition from healthy aging to mild cognitive impairment, with a focus on how peripheral immune challenges can trigger transient but maladaptive neuroimmune signaling that leads to long-lasting synaptic, mitochondrial, and cognitive dysfunction. Across his work at both California State University and Ohio State University, Bryan’s research has increasingly focused on sex differences in these mechanisms to help inform the development of clinically relevant therapeutics.