Investigating the Role of CNS-Expanded Innate-Like B-cells in a Mouse Model of Progressive Multiple Sclerosis

Progressive multiple sclerosis remains poorly understood, particularly the role of B-cells in driving chronic inflammatory demyelination. Using a novel age-dependent EAE model, we identified a subset of innate-like B cells (ACE B-cells) that accumulate and clonally expand in the CNS of middle-aged mice, potentially exacerbating neuroinflammation through encephalitogenic T-cell reactivation and antibody production against myelin components. This proposal aims to elucidate the mechanisms driving ACE B-cell recruitment and their contribution to disease progression, while also providing the PI with critical training to support her development as an independent investigator.

Hayley is on a winning streak!

Her abstract was recently selected for a young investigator platform oral presentation at the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) forum, and she was awarded the best young investigator oral presentation award. Additionally, her abstract was selected for a short talk at the Keystone Conference: "B Cells and Plasma Cells: Fundamental and Translational Biology"