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New Paper from Olivia Taylor

September 18, 2025

New Paper from Olivia Taylor

Liv Taylor Nov 2025 J Neurosci

Olivia “Liv” Taylor, PhD 2025 

“Sphingosine-1-phosphate signaling through Müller glia regulates neuroprotection, accumulation of immune cells, and neuronal regeneration in the rodent retina” Journal of Neuroscience 2025.   

Understanding the mechanisms of retinal neuron survival and regeneration is fundamental for the development of therapeutic strategies of retinal repair. This study provides evidence that Sphingosine-1-phosphate signaling “kick-starts” the glial pro-inflammatory response, restricts immune cell recruitment, and exacerbates neuron cell death after acute retinal injury. Importantly, blocking sphingosine-1-phosphate activity enhances Ascl1-driven neurogenesis in the mouse retina, highlighting a potential therapeutic target for retinal regeneration. These findings indicate that the S1P-signaling pathway is activated in MG after damage and this pathway acts secondarily to restrict the accumulation of immune cells, impairs neuron survival and suppresses the reprogramming of MG into neurogenic progenitors in the adult mouse retina.

link to paper