
Olivia Taylor
Advisor: Andrew Fischer
She/Her/Hers
taylor.3878@buckeyemail.osu.edu
3140 Graves Hall
333 W. 10th Avenue
Columbus, OH 43210
Areas of Expertise
- Molecular and Cellular Neuroscience
Education
- BS in Biology (2020), California University of Pennsylvania
Research
In Fischer lab, I study several aspects of retinal development and regeneration. Particularly, I investigate the signaling pathways that mediate Muller glia reprogramming in the early postnatal chick and adult murine retina. In lower vertebrates, acute injury and growth factors facilitate Muller glia reprogramming into progenitor-like cells. These progenitors proliferate and differentiate into neurons to restore vision. We study mechanisms of progenitor cell formation and neurogenesis using single cell transcriptomic and epigenomic analyses, pharmacological agents, and Muller glia-targeted genetic manipulations.
Papers
- O.Taylor, N. DeGroff, H.M. El-Hodiri, C. Gao and A.J. Fischer (2024) Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells. (under review) BioRxiv [Preprint]. 2024 Aug 6:2024.08.06.606815.
- O. Taylor, S. Patel, E.C. Hawthorn, H.M. El-Hodiri, and A.J. Fischer (2024). ID factors regulate the ability of Müller glia to become proliferating neurogenic progenitor-like cells. Glia 72:1236-1258 PMID: 38515287.
- H.M. El-Hodiri, J. Bentley, A. Reske, O. Taylor, I. Palazzo*, W.A. Campbell*, N.R. Halloy* and A.J. Fischer (2023). Heparin-binding epidermal growth factor (HBEGF) and fibroblast growth factor 2 (FGF2) rescue the deficit in the formation of Müller glia-derived progenitor cells in retinas missing microglia and macrophage. Development. 150: dev.202070.
*NGP students
Link to Olivia Taylor's papers on Pubmed