The Wang lab is interested to elucidate the mechanisms and roles of autophagy, a “self-eating” process inside cells to keep tissue homeostasis and energy balance under physiological and pathological conditions in neurodevelopment and brain diseases. We employed transgenic mouse models, primary cell culture, and iPSC-derived cerebral organoids to study autophagy genes in neurodevelopmental disorder of tuberous sclerosis complex (TSC), breast cancer to brain metastasis, and Alzheimer’s disease.